In a pre-clinical study selamectin was dosed orally to ivermectin-sensitive collies. Higher doses were not tested. Dogs and cats treated with Paradyne, including those with pre-existing flea allergy dermatitis, showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas from the animals and their environment. Updated: 2020-09-29. Distributed by: Vicar Operating, Inc., 12401 West Olympic Blvd., Los Angeles, CA 90064, Manufactured by: Zoetis Inc., Kalamazoo, MI 49007, Copyright © 2020 Animalytix LLC. Hypersensitivity reactions have not been observed in dogs with patent heartworm infections administered three times the recommended dose of Paradyne. We comply with the HONcode standard for trustworthy health information -, Direction and dosage information for Paradyne. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of Paradyne against heartworm. Paradyne also was applied at 4 times the recommended dose to patent heartworm infected cats, and no adverse reactions were observed. A kitten, estimated to be 5-6 weeks old (0.3 kg), died 8 1/2 hours after receiving a single treatment of Paradyne at the recommended dosage. The originating document has been archived. For cats over 22 lbs use the appropriate combination of tubes. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Paradyne topically to dogs and cats prior to first use. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of Paradyne and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. A list of US medications equivalent to Paradine is available on the Drugs.com website. The material safety data sheet (MSDS) provides more detailed occupational safety information. Paradyne (selamectin) Topical Parasiticide is available as a colorless to yellow, ready to use solution in single dose tubes for topical (dermal) treatment of dogs six weeks of age and older and cats eight weeks of age and older. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Paradyne should be administered once as a single topical dose. There have also been rare reports of seizures in dogs (see WARNINGS). In case of ingestion by a human, contact a physician immediately. The safety of Paradyne administered orally also was tested in case of accidental oral ingestion. Paradyne has been tested safe in over 100 different pure and mixed breeds of healthy dogs and over 15 different pure and mixed breeds of healthy cats, including pregnant and lactating females, breeding males and females, puppies six weeks of age and older, kittens eight weeks of age and older, and avermectin-sensitive collies. Cleansing of the infested ears is recommended to remove the debris. Paradyne kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Select one or more newsletters to continue. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. The content of each tube is formulated to provide a minimum of 2.7 mg/lb (6 mg/kg) of body weight of selamectin. Do not use in sick, debilitated or underweight animals (see SAFETY). Avoid contact between the product and fingers. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of Paradyne must be given within a month of the last dose of the former medication. In addition to the aforementioned clinical signs that were reported in pre-approval clinical trials, there have been reports of pruritus, urticaria, erythema, ataxia, fever, and rare reports of death. The safety of Paradyne administered orally also was tested in case of accidental oral ingestion. In controlled laboratory studies >98% of fleas were killed within 36 hours. Not for human use. DOGS: In safety studies, Paradyne was administered at 1, 3, 5, and 10 times the recommended dose to six-week-old puppies, and no adverse reactions were observed. Available for Android and iOS devices. If the dog or cat is already infested with fleas when the first dose of Paradyne is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. Wash hands after use and wash off any product in contact with the skin immediately with soap and water. Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Paradyne topically in accordance with the following tables. Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. We comply with the HONcode standard for trustworthy health information -. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Firmly press the cap down to puncture the seal on the Paradyne tube; a clicking sound will confirm that the cap has successfully punctured the seal. For dogs over 130 lbs use the appropriate combination of tubes. These effects are temporary and do not affect the safety or effectiveness of the product. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Do not massage the product into the skin. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Do not apply when the haircoat is wet. Remove the cap and check to ensure that the tip of the tube is open. Monthly use of Paradyne will control any subsequent sarcoptic mange mite infestations. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. STORAGE CONDITIONS: Store below 30°C (86°F). Following treatment with Paradyne, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Discard empty tubes in your ordinary household refuse. Paradine may be available in the countries listed below. For the prevention and control of flea infestations, Paradyne should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. (See ADMINISTRATION for the recommended treatment intervals.). In a topical safety study conducted with avermectin-sensitive collies at 1, 3 and 5 times the recommended dose of Paradyne, salivation was observed in all treatment groups, including the vehicle control. A second monthly dose may be required in some dogs. In the clinical field trials ears were not cleaned, and many animals still had debris in their ears after the second dose. Every effort has been made to ensure the accuracy of the Paradyne information published above. A second monthly dose may be required in some dogs. US Federal law restricts this drug to use by or on the order of a licensed veterinarian. For the prevention of heartworm disease, Paradyne must be administered on a monthly basis. The kitten displayed clinical signs which included muscle spasms, salivation and neurological signs. In humans, Paradyne may be irritating to skin and eyes. The chemical composition of selamectin is (5Z,25S) - 25 - cyclohexyl - 4’ - O - de(2,6 - dideoxy - 3 - O - methyl - α - L - arabino - hexopyranosyl) - 5 - demethoxy - 25 - de(1 - methylpropyl) - 22,23 - dihydro - 5 - hydroxyiminoavermectin A1a. Paradine is a medicine available in a number of countries worldwide. Keep out of the reach of children. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Results of clinical field studies using Paradyne monthly demonstrated >90% control of flea infestations within 30 days of the first dose. Data sources include IBM Watson Micromedex (updated 1 Oct 2020), Cerner Multum™ (updated 1 Oct 2020), Wolters Kluwer™ (updated 30 Sep 2020) and others. Oral administration of Paradyne at the recommended topical dose in 5- to 8-month-old beagles did not cause any adverse reactions. Resolution of the pruritus associated with the mite infestations was observed in approximately 50% of the dogs 30 days after the first treatment and in approximately 90% of the dogs 30 days after the second monthly treatment. Available for Android and iOS devices. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of Paradyne against fleas or heartworm. Because of the difficulty in finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on resolution of clinical signs. In heavy tick infestations, complete efficacy may not be achieved after the first dose. For the treatment and control of intestinal hookworm (A. tubaeforme) and roundworm (T. cati) infections, Paradyne should be applied once as a single topical dose.